Description

5'-Azido-2',5'-Dideoxy-2'-Fluorouridine is a modified nucleoside analog featuring an azido group at the 5'-position and a fluorine atom at the 2'-position. This compound is a critical building block and key intermediate in the synthesis of novel antiviral and anticancer agents, particularly within the field of nucleoside-based prodrug development. It is essential for pharmaceutical R&D, enabling the creation of targeted therapies that inhibit viral replication and cancer cell proliferation. Researchers and manufacturers in advanced pharmaceutical synthesis rely on this high-purity intermediate for its precise chemical functionality.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel nucleoside analog prodrugs with antiviral and anticancer activities.
• Antiviral Drug Research: Used in the development of potential therapeutics targeting viruses such as hepatitis C (HCV) and other RNA viruses.
• Oncology Research: Serves as a building block for creating compounds that inhibit cancer cell growth by interfering with DNA/RNA synthesis.
• ProTide Technology: A crucial component in the synthesis of phosphoramidate prodrugs, enhancing cell membrane permeability and intracellular delivery of active metabolites.
• Biochemical Tool: Employed in mechanistic studies to understand enzyme kinetics and inhibition pathways of viral polymerases.
• Medicinal Chemistry: Used for structure-activity relationship (SAR) studies to optimize the potency and selectivity of nucleoside therapeutics.

Basic Information

Product Name	5'-Azido-2',5'-Dideoxy-2'-Fluorouridine
CAS No.	1012080-88-4
Molecular Formula	C9H10FN5O5
Molecular Weight	287.21 g/mol
Synonyms	2'-Fluoro-2',5'-dideoxy-5'-azidouridine; 5'-Azido-2'-fluoro-2',5'-dideoxyuridine; 1-((2R,3R,5R)-5-Azido-3-fluoro-2,5-dihydroxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 2'-F-5'-N3-2',5'-ddU; 5'-N3-2'-F-2',5'-ddU; Azido-fluoro-dideoxyuridine; A Fluorinated Nucleoside Azide Intermediate
EINECS	Contact for details

Quality Control

Our 5'-Azido-2',5'-Dideoxy-2'-Fluorouridine is manufactured under strict quality systems to ensure batch-to-batch consistency for research and production. It undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing all specified parameters. Our quality commitment supports compliance with cGMP guidelines for pharmaceutical intermediates, ensuring reliability for critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed in a desiccated environment to maintain stability and purity. Handle and store in accordance with all applicable laboratory safety regulations.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.