Description

tert-Butyl 6-Chloro-4-Oxospiro[Chroman-2,4'-Piperidine]-1'-Carboxylate CAS NO 1011482-37-3 is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and piperidine scaffold. This compound is of significant value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is primarily sought by pharmaceutical R&D organizations, contract research and manufacturing organizations (CROs/CMOs), and fine chemical suppliers engaged in developing next-generation therapeutics.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• CNS Drug Development: The spiro[chroman-2,4'-piperidine] core structure is relevant for research into neurological and psychiatric disorders.
• Oncology Research: Serves as a building block for potential kinase inhibitors and other targeted cancer therapies.
• Process Chemistry & Scale-Up: Supplied to support route scouting, optimization, and pilot-scale manufacturing of clinical trial materials.
• Academic & Institutional Research: Utilized in universities and research institutes for chemical biology and pharmacological studies.

Basic Information

Product Name	tert-Butyl 6-Chloro-4-Oxospiro[Chroman-2,4'-Piperidine]-1'-Carboxylate
CAS No.	1011482-37-3
Molecular Formula	C18H22ClNO4
Molecular Weight	351.83 g/mol
Synonyms	1'-Boc-6-chloro-4-oxospiro[chroman-2,4'-piperidine]; tert-Butyl 6-chloro-4-oxo-1'H-spiro[chroman-2,4'-piperidine]-1'-carboxylate; 6-Chloro-1'H-spiro[chroman-2,4'-piperidine]-4-one, 1'-(1,1-dimethylethyl) ester; 1'-(tert-Butoxycarbonyl)-6-chloro-4-oxospiro[chroman-2,4'-piperidine]; Boc-6-chloro-4-oxospiro[chroman-2,4'-piperidine]; 1011482-37-3; Spiro[chroman-2,4'-piperidine]-4-one, 6-chloro-1'-(1,1-dimethylethyl) 1'-carboxylate
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 6-Chloro-4-Oxospiro[Chroman-2,4'-Piperidine]-1'-Carboxylate adheres to stringent quality management protocols. Every batch is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment, ensuring full traceability and compliance with your research or manufacturing requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.