Description

5-Chloro-1-(4-Fluorophenyl)-3,6-Dimethyl-1H-Pyrazolo[3,4-B]Pyridine-4-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is essential for research and development chemists and manufacturers in the pharmaceutical and biotechnology sectors seeking to develop new drug candidates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially in oncology and central nervous system (CNS) therapeutic research.
• API Development: Serves as a core structural motif for the development of new Active Pharmaceutical Ingredients (APIs) with potential kinase inhibitory or receptor-modulating activity.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Biochemical Tool Compound: Employed in biochemical assays and as a reference standard in pharmacological research.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs engaged in custom synthesis projects.

Basic Information

Product Name	5-Chloro-1-(4-Fluorophenyl)-3,6-Dimethyl-1H-Pyrazolo[3,4-B]Pyridine-4-Carboxylic Acid
CAS No.	1011399-89-5
Molecular Formula	C17H13ClFN3O2
Molecular Weight	345.76 g/mol
Synonyms	5-Chloro-1-(4-fluorophenyl)-3,6-dimethyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid; 1H-Pyrazolo[3,4-b]pyridine-4-carboxylic acid, 5-chloro-1-(4-fluorophenyl)-3,6-dimethyl-; 1011399-89-5; 5-Chloro-1-(p-fluorophenyl)-3,6-dimethyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid; 4-Pyrazolo[3,4-b]pyridinecarboxylic acid, 5-chloro-1-(4-fluorophenyl)-3,6-dimethyl-
EINECS	Contact for details

Quality Control

Our 5-Chloro-1-(4-Fluorophenyl)-3,6-Dimethyl-1H-Pyrazolo[3,4-B]Pyridine-4-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.