Description

5-Chloro-6-Cyclopropyl-1-(2-Fluorophenyl)-3-Methyl-1H-Pyrazolo[3,4-B]Pyridine-4-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is a critical building block in modern medicinal chemistry, valued for its role in synthesizing novel active pharmaceutical ingredients (APIs). It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly in areas requiring sophisticated molecular scaffolds.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used as a core scaffold in structure-activity relationship (SAR) studies and lead optimization programs.
• API Development: Integral in the multi-step synthesis of potential Active Pharmaceutical Ingredients (APIs), especially for central nervous system (CNS) or anti-inflammatory targets.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up for clinical trial material production.
• Biochemical Tool Compound: May be utilized in biochemical assays to study specific enzyme inhibition or receptor binding.

Basic Information

Product Name	5-Chloro-6-Cyclopropyl-1-(2-Fluorophenyl)-3-Methyl-1H-Pyrazolo[3,4-B]Pyridine-4-Carboxylic Acid
CAS No.	1011397-82-2
Molecular Formula	C18H13ClFN3O2
Molecular Weight	357.77 g/mol
Synonyms	5-Chloro-6-cyclopropyl-1-(2-fluorophenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid; 1H-Pyrazolo[3,4-b]pyridine-4-carboxylic acid, 5-chloro-6-cyclopropyl-1-(2-fluorophenyl)-3-methyl-; 1011397-82-2; 5-Chloro-6-cyclopropyl-1-(2-fluorophenyl)-3-methylpyrazolo[3,4-b]pyridine-4-carboxylic acid; Fluorophenyl-methyl-pyrazolopyridine carboxylic acid derivative
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and scale-up work. Identity, purity, and impurity profiles are verified using advanced analytical techniques including HPLC, GC, and NMR. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.