Description

5-Chloro-6-Cyclopropyl-3-Methyl-1-(4-Methylbenzyl)-1H-Pyrazolo[3,4-B]Pyridine-4-Carboxylic Acid CAS NO 1011397-37-7 is a high-purity, advanced pharmaceutical intermediate characterized by its complex pyrazolopyridine core structure. This compound is of significant commercial importance for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and manufacturing organizations within the pharmaceutical and biotechnology sectors engaged in drug discovery and development programs.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the research and production of new therapeutic agents.
• Drug Discovery Research: Utilized in medicinal chemistry for the design and synthesis of novel small-molecule drug candidates targeting various disease pathways.
• API Synthesis: A crucial building block in multi-step synthetic routes for the manufacture of complex final active pharmaceutical ingredients.
• Biochemical Research: Employed in the development of chemical probes and inhibitors for studying biological processes at the molecular level.
• Contract Manufacturing (CMO/CDMO): Supplied to contract development and manufacturing organizations for cGMP-compliant production of clinical trial materials and commercial APIs.
• Library Synthesis: Used in combinatorial chemistry to create diverse compound libraries for high-throughput screening.

Basic Information

Product Name	5-Chloro-6-Cyclopropyl-3-Methyl-1-(4-Methylbenzyl)-1H-Pyrazolo[3,4-B]Pyridine-4-Carboxylic Acid
CAS No.	1011397-37-7
Molecular Formula	C20H18ClN3O2
Molecular Weight	367.83 g/mol
Synonyms	5-Chloro-6-cyclopropyl-3-methyl-1-[(4-methylphenyl)methyl]pyrazolo[3,4-b]pyridine-4-carboxylic acid; 1H-Pyrazolo[3,4-b]pyridine-4-carboxylic acid, 5-chloro-6-cyclopropyl-3-methyl-1-[(4-methylphenyl)methyl]-; 5-Chloro-6-cyclopropyl-3-methyl-1-(4-methylbenzyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid; CAS 1011397-37-7
EINECS	Contact for details

Quality Control

Our production of 5-Chloro-6-Cyclopropyl-3-Methyl-1-(4-Methylbenzyl)-1H-Pyrazolo[3,4-B]Pyridine-4-Carboxylic Acid adheres to stringent quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality systems are designed to support cGMP compliance for pharmaceutical applications, and we maintain full traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed in a dry environment. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.