Description

4-(4-Bromo-2-Fluorophenyl)-4,5,6,7-Tetrahydro-3H-Imidazo[4,5-C]Pyridine is a high-value, heterocyclic organic compound featuring a fused imidazopyridine core, which is of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block (advanced intermediate) for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas targeting the central nervous system and oncology. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel drug candidates, especially kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Chemical Biology Probes: Serves as a core structure for developing molecular probes to study biological pathways and protein functions.
• Process Development & Scale-up: Employed in route scouting, optimization, and pilot-scale synthesis for new chemical entities (NCEs).
• Reference Standard: Supplied as a high-purity standard for analytical method development and quality control in API manufacturing.

Basic Information

Product Name	4-(4-Bromo-2-Fluorophenyl)-4,5,6,7-Tetrahydro-3H-Imidazo[4,5-C]Pyridine
CAS No.	1010881-22-7
Molecular Formula	C12H11BrFN3
Molecular Weight	296.14 g/mol
Synonyms	4-(4-Bromo-2-fluorophenyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine; 4-(4-Bromo-2-fluorophenyl)-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridine; 1H-Imidazo[4,5-c]pyridine, 4-(4-bromo-2-fluorophenyl)-4,5,6,7-tetrahydro-; 4-(4-Bromo-2-fluorophenyl)-1,4,5,6,7,8-hexahydroimidazo[4,5-c]pyridine; SCHEMBL2188307; AKOS025247213; BCP31363; ZINC000257830911
EINECS	Contact for details

Quality Control

Our production of 4-(4-Bromo-2-Fluorophenyl)-4,5,6,7-Tetrahydro-3H-Imidazo[4,5-C]Pyridine adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. All materials are characterized and released against comprehensive specifications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity (typically ≥95% by HPLC), and impurity profiles. Our quality system supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0% Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.