Description

5-Bromo-N,n-Diethyl-2-Fluoronicotinamide is a high-purity fluorinated nicotinamide derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its value lies in enabling the precise construction of complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is essential for research and development chemists and process scale-up teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce fluorine and bromine substituents for tuning bioactivity and physicochemical properties.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of fluorinated drug candidates, including kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Research: Used in developing novel herbicides, fungicides, and insecticides where the fluorine atom enhances metabolic stability and bioavailability.
• Chemical Biology Probe Synthesis: Employed in creating tagged molecules for studying enzyme function and biological pathways.
• Material Science Precursor: Serves as a monomer or functionalization agent for advanced polymers and liquid crystals.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for client projects.
• Academic Research: Utilized in university and institutional labs for methodological studies in heterocyclic and fluoroorganic chemistry.

Basic Information

Product Name	5-Bromo-N,n-Diethyl-2-Fluoronicotinamide
CAS No.	1010836-38-0
Molecular Formula	C10H12BrFN2O
Molecular Weight	275.12 g/mol
Synonyms	5-Bromo-2-fluoro-N,N-diethylnicotinamide; 2-Fluoro-5-bromo-N,N-diethylnicotinamide; Nicotinamide, 5-bromo-2-fluoro-N,N-diethyl-; 1010836-38-0; 5-Bromo-N,N-diethyl-2-fluoropyridine-3-carboxamide; 3-Pyridinecarboxamide, 5-bromo-2-fluoro-N,N-diethyl-
EINECS	Contact for details

Quality Control

Our 5-Bromo-N,n-Diethyl-2-Fluoronicotinamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the stringent requirements of our global clientele. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container must be kept tightly closed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.