Description

4-Chloro-2-Ethynyl-Pyridine is a high-value, multi-functional heterocyclic building block featuring both a halogen and an alkyne functional group. This unique structure makes it a critical intermediate for the synthesis of complex molecules in advanced research and development. It is primarily sought after by pharmaceutical, agrochemical, and material science industries for applications in drug discovery, ligand synthesis, and the creation of novel polymers.

Application

• Pharmaceutical Intermediate: A key synthon for constructing active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging its reactive sites for structural diversification.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in coordination chemistry and catalysis, especially in cross-coupling reactions.
• Material Science & Polymer Chemistry: The ethynyl group enables its use in click chemistry (e.g., CuAAC) for constructing functionalized polymers, dendrimers, and advanced materials.
• Chemical Biology & Bioconjugation: Employed as a linker or tagging agent for modifying biomolecules, proteins, and nucleic acids in probe development.
• Organic Electronic Materials: A building block for synthesizing conjugated molecules and small-molecule semiconductors for OLEDs and OFETs.

Basic Information

Item	Detail
Product Name	4-Chloro-2-Ethynyl-Pyridine
CAS No.	1010115-57-7
Molecular Formula	C7H4ClN
Molecular Weight	137.57 g/mol
Synonyms	2-Ethynyl-4-chloropyridine; 4-Chloro-2-ethynylpyridine; 4-Chloro-2-pyridylacetylene; 2-(4-Chloropyridin-2-yl)acetylene; (4-Chloro-2-pyridinyl)ethyne; 4-Chloro-2-ethynyl-pyridine; 4-Chloro-2-(ethynyl)pyridine
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Ethynyl-Pyridine is produced under strict quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and industry best practices for research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This compound is light-sensitive and should be handled under an inert atmosphere for long-term stability. Keep away from strong oxidizers and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.