Description

trans-3-Piperidinecarboxylic Acid, 6-Methyl-, Methyl Ester is a high-purity, synthetically valuable piperidine derivative. This compound serves as a crucial chiral building block and intermediate in advanced organic synthesis, particularly for the development of active pharmaceutical ingredients (APIs). It is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to construct complex nitrogen-containing molecular architectures.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of novel drug candidates, including potential central nervous system (CNS) agents, receptor modulators, and enzyme inhibitors.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging its piperidine scaffold for biological activity.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands used in asymmetric catalysis, enhancing stereoselectivity in chemical transformations.
• Fine Chemical Synthesis: A versatile intermediate for constructing complex natural products and specialty chemicals requiring a functionalized piperidine moiety.
• Academic & R&D: Employed in medicinal chemistry research for structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	trans-3-Piperidinecarboxylic Acid, 6-Methyl-, Methyl Ester
CAS No.	1009376-87-7
Molecular Formula	C8H15NO2
Molecular Weight	157.21 g/mol
Synonyms	Methyl (3R,6R)-6-methylpiperidine-3-carboxylate; Methyl trans-6-methylnipecotate; trans-6-Methylnipecotic acid methyl ester; (3R,6R)-6-Methylpiperidine-3-carboxylic acid methyl ester; 6-Methylnipecotic Acid Methyl Ester (trans); trans-3-Carbomethoxy-6-methylpiperidine; Methyl trans-3-piperidinecarboxylate, 6-methyl-
EINECS	Contact for details

Quality Control

Every batch of trans-3-Piperidinecarboxylic Acid, 6-Methyl-, Methyl Ester is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including chiral HPLC, to ensure high chemical and enantiomeric purity, meeting the stringent requirements of advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee (trans isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.