Description

(3R,6S)-3-Piperidinecarboxylic Acid, 6-Methyl-, Methyl Ester is a high-purity chiral piperidine derivative, a crucial building block in modern pharmaceutical synthesis. Its defined stereochemistry and ester functionality make it an invaluable intermediate for constructing complex molecules with specific biological activity. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly in areas requiring precise chiral control.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, including central nervous system (CNS) drugs and enzyme inhibitors.
• Asymmetric Synthesis: Used as a building block in stereoselective chemical reactions to introduce the (3R,6S)-piperidine motif into target molecules.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Chemical Reference Standard: Serves as a high-purity standard for analytical method development and quality control in API manufacturing.
• Peptidomimetics: Utilized in the design and synthesis of peptide analogs and conformationally restricted scaffolds.

Basic Information

Product Name	(3R,6S)-3-Piperidinecarboxylic Acid, 6-Methyl-, Methyl Ester
CAS No.	1009376-81-1
Molecular Formula	C8H15NO2
Molecular Weight	157.21 g/mol
Synonyms	Methyl (3R,6S)-6-methylnipecotate; (3R,6S)-6-Methylnipecotic acid methyl ester; Methyl (3R,6S)-6-methylpiperidine-3-carboxylate; (3R,6S)-1,2,3,6-Tetrahydropyridine-3-carboxylic acid, 6-methyl-, methyl ester; (3R,6S)-6-Methyl-3-piperidinecarboxylic acid methyl ester; L-Nipecotic acid, 6-methyl-, methyl ester, (3R,6S)-; (3R,6S)-6-Methyl-3-carbomethoxypiperidine
EINECS	Contact for details

Quality Control

Our (3R,6S)-3-Piperidinecarboxylic Acid, 6-Methyl-, Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) providing identity, purity, and impurity profile is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.