Description

4-Chloro-5-Fluoronicotinonitrile is a high-value, multi-functional heterocyclic building block essential for modern synthetic chemistry. This compound matters as a key intermediate in the development of advanced pharmaceuticals and agrochemicals, enabling the precise construction of complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, leveraging its halogenated pyridine core.
• Material Science Research: Serves as a building block for creating specialized ligands, organic semiconductors, and photoactive materials.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects and scale-up processes in CDMO (Contract Development and Manufacturing Organization) settings.

Basic Information

Item	Details
Product Name	4-Chloro-5-Fluoronicotinonitrile
CAS No.	1009334-65-9
Molecular Formula	C6H2ClFN2
Molecular Weight	156.55 g/mol
Synonyms	4-Chloro-5-fluoropyridine-3-carbonitrile; 3-Cyano-4-chloro-5-fluoropyridine; 5-Fluoro-4-chloronicotinonitrile; 4-Chloro-5-fluoro-3-pyridinecarbonitrile; 4-Chloro-5-fluoronicotinamide nitrile (precursor); 1009334-65-9 (CAS Registry); 4-Chloro-5-fluoro-3-cyanopyridine
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-5-Fluoronicotinonitrile is produced under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.