Description

1-(2,3,5,6-Tetramethylphenylsulfonyl)-L-Proline, 96% is a high-purity, chiral sulfonamide derivative of L-proline, serving as a critical building block in advanced organic synthesis. This compound matters for its role as a specialized intermediate in the development of pharmaceuticals and fine chemicals, where its defined stereochemistry and functional groups enable precise molecular construction. It is primarily needed by research institutions and industrial R&D departments focused on medicinal chemistry, process development, and the synthesis of complex bioactive molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting protease inhibition or requiring chiral proline scaffolds.
• Peptidomimetic Research: Used in the design and synthesis of peptidomimetics and constrained peptides to improve metabolic stability and bioavailability.
• Asymmetric Synthesis Catalyst/Chiral Auxiliary: Employed as a precursor or component in chiral catalysts or auxiliaries for enantioselective transformations.
• Chemical Biology Probes: Utilized in the development of chemical probes and tool compounds for studying enzyme function and biological pathways.
• Process Chemistry Development: Serves as a starting material or intermediate in the scale-up and optimization of synthetic routes for complex molecules.
• Fine Chemical Synthesis: Intermediate for the production of specialty chemicals, agrochemicals, and advanced materials requiring specific sulfonamide functionality.

Basic Information

Product Name	1-(2,3,5,6-Tetramethylphenylsulfonyl)-L-Proline, 96%
CAS No.	1009282-06-7
Molecular Formula	C15H21NO4S
Molecular Weight	311.40 g/mol
Synonyms	L-Proline, 1-[(2,3,5,6-tetramethylphenyl)sulfonyl]-; 1-(2,3,5,6-Tetramethylbenzenesulfonyl)-L-proline; 1-(2,3,5,6-Tetramethylphenylsulfonyl)proline; (S)-1-(2,3,5,6-Tetramethylphenylsulfonyl)pyrrolidine-2-carboxylic acid; Tps-Pro-OH; 2,3,5,6-Tetramethylbenzenesulfonyl-L-proline; Tetramethylphenylsulfonyl proline derivative; Proline sulfonamide derivative
EINECS	Contact for details

Quality Control

Our 1-(2,3,5,6-Tetramethylphenylsulfonyl)-L-Proline, 96% undergoes rigorous quality testing to ensure compliance with industry standards for research and development chemicals. Each batch is analyzed to confirm identity, purity, and chiral integrity. Certificates of Analysis (COA) detailing specific test results, including assay by HPLC and chiral purity, are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 96.0%
Chiral Purity (HPLC)	≥ 99.0% ee (L-isomer)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.