Description

Methyl 1-(4-Biphenylylcarbonyl)Prolinate is a specialized organic compound featuring a biphenyl carbonyl moiety esterified with a prolinate derivative. This molecular architecture makes it a valuable advanced pharmaceutical intermediate and a versatile building block for complex organic synthesis. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and fine chemical sectors for developing novel active ingredients and high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders or acting as enzyme inhibitors.
• Protease Inhibitor Research: Serves as a core structure or precursor in the development of protease inhibitors due to the prolinate moiety.
• Ligand and Catalyst Development: Used in academic and industrial research to create novel chiral ligands or organocatalysts for asymmetric synthesis.
• Peptidomimetic Synthesis: Integral component for constructing peptidomimetics, which are molecules that mimic peptides but with enhanced stability and bioavailability.
• Material Science Research: Potential monomer or additive in the development of specialty polymers with specific optical or electronic properties.
• Chemical Reference Standard: Supplied as a high-purity standard for analytical method development, quality control, and regulatory submissions in pharmaceutical labs.

Basic Information

Product Name	Methyl 1-(4-Biphenylylcarbonyl)Prolinate
CAS No.	1009278-53-8
Molecular Formula	C19H19NO3
Molecular Weight	309.36 g/mol
Synonyms	Methyl 1-[(1,1'-biphenyl)-4-carbonyl]-2-pyrrolidinecarboxylate; L-Prolinamide, 1-[(1,1'-biphenyl)-4-carbonyl]-N-methoxy-; Methyl 1-(4-phenylbenzoyl)-L-prolinate; 1-[(1,1'-Biphenyl)-4-carbonyl]-L-proline methyl ester; (S)-Methyl 1-([1,1'-biphenyl]-4-carbonyl)pyrrolidine-2-carboxylate; Methyl (S)-1-([1,1'-biphenyl]-4-carbonyl)pyrrolidine-2-carboxylate; Biphenyl-4-carboxylic acid (S)-1-methoxycarbonyl-pyrrolidin-1-yl ester
EINECS	Contact for details

Quality Control

Our Methyl 1-(4-Biphenylylcarbonyl)Prolinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment. We can support development with custom purity grades, including research, development, and cGMP grades for advanced clinical stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to protect the compound from moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.