Description

(2E)-6-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-2-Hexenoic Acid Ethyl Ester is a high-purity, protected amino acid derivative essential for advanced organic synthesis. This compound serves as a critical chiral building block and key intermediate in the development of complex pharmaceutical molecules and bioactive peptides. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for constructing novel therapeutic agents and conducting process chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for peptide-based drugs and enzyme inhibitors.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected glutamic acid or ornithine analog for constructing specific peptide sequences.
• Protease Inhibitor Development: Serves as a core structural component in the research and production of protease inhibitors for therapeutic applications.
• Chemical Biology Research: Employed as a molecular tool for studying enzyme-substrate interactions and designing activity-based probes.
• Fine Chemical Synthesis: Acts as a versatile intermediate for creating complex natural product analogs and other specialty organic compounds.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Item	Details
Product Name	(2E)-6-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-2-Hexenoic Acid Ethyl Ester
CAS No.	1008751-73-2
Molecular Formula	C14H25NO5
Molecular Weight	287.35 g/mol
Synonyms	Ethyl (2E)-6-[(tert-Butoxycarbonyl)amino]-2-hexenoate; Boc-NH-(CH2)3-CH=CH-COOEt; (E)-Ethyl 6-((tert-butoxycarbonyl)amino)hex-2-enoate; N-Boc-4-Aminobut-2-enoic Acid Ethyl Ester; Nα-Boc-L-2,4-Diaminobutanoic Acid Ethyl Ester derivative; Protected Amino Acid Ester; Boc-Amino Hexenoate Ethyl Ester
EINECS	Contact for details

Quality Control

Every batch of (2E)-6-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-2-Hexenoic Acid Ethyl Ester is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity suitable for sensitive synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is stable under recommended conditions but should be kept away from strong acids and organic solvents as indicated by its chemical properties. For long-term storage, consider inert atmosphere handling to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Isomeric Purity (E/Z Ratio)	≥ 98:2 (E:Z)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.