Description

4-Chloro-2-Methoxypyridine-3-Carbonitrile is a versatile and high-value pyridine derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its unique substitution pattern makes it a key building block for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs). This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific functional groups into heterocyclic systems.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, leveraging its halogen and nitrile functionality.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in metal-catalyzed cross-coupling reactions.
• Material Science Research: Employed in the synthesis of functionalized heterocycles for organic electronic materials and dyes.
• Chemical Biology Probes: Utilized to build molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis and Contract Manufacturing: A fundamental building block for custom synthesis projects and scale-up production under cGMP conditions.

Basic Information

Product Name	4-Chloro-2-Methoxypyridine-3-Carbonitrile
CAS No.	1008451-56-6
Molecular Formula	C7H5ClN2O
Molecular Weight	168.58 g/mol
Synonyms	3-Cyano-4-chloro-2-methoxypyridine; 4-Chloro-2-methoxy-3-pyridinecarbonitrile; 2-Methoxy-4-chloropyridine-3-carbonitrile; 4-Chloro-2-methoxynicotinonitrile; 3-Pyridinecarbonitrile, 4-chloro-2-methoxy-; 1008451-56-6; 4-Chloro-2-methoxypyridine-3-carbonitrile
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-2-Methoxypyridine-3-Carbonitrile is produced and tested under strict quality management protocols to ensure consistency and reliability for your synthesis. We provide comprehensive analytical data including HPLC purity, NMR, and mass spectrometry confirmation. A detailed Certificate of Analysis (COA) is supplied with each shipment, and we support compliance with relevant regulatory frameworks including REACH and ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.