Description

Methyl 1-(3-Iodo-4-Methoxybenzoyl)Prolinate is a high-purity, non-natural amino acid derivative characterized by its unique halogenated aromatic structure. This compound serves as a critical advanced pharmaceutical intermediate (API intermediate) for the synthesis of complex bioactive molecules. It is primarily utilized by research institutions and pharmaceutical R&D departments engaged in developing novel therapeutic agents, particularly in medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, especially protease inhibitors and other enzyme-targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its modifiable prolinate ester and iodinated aromatic ring.
• Peptidomimetic Development: Serves as a constrained amino acid analog in the design of peptide-like molecules with enhanced metabolic stability and bioavailability.
• Chemical Biology Probes: Can be incorporated into molecules designed to study enzyme function or protein-protein interactions, leveraging the iodine atom for potential labeling or as a heavy atom.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for the bespoke production of client-specific target compounds.

Basic Information

Product Name	Methyl 1-(3-Iodo-4-Methoxybenzoyl)Prolinate
CAS No.	1008411-81-1
Molecular Formula	C14H16INO4
Molecular Weight	389.19 g/mol
Synonyms	Methyl (2S)-1-[(3-iodo-4-methoxyphenyl)carbonyl]pyrrolidine-2-carboxylate; L-Proline, 1-[(3-iodo-4-methoxyphenyl)carbonyl]-, methyl ester; Methyl 1-(3-iodo-p-anisoyl)-L-prolinate; 1-(3-Iodo-4-methoxybenzoyl)-L-proline methyl ester; Methyl O-(3-iodo-4-methoxybenzoyl)-L-prolinate; (S)-Methyl 1-(3-iodo-4-methoxybenzoyl)pyrrolidine-2-carboxylate; Prolinate iodoanisoyl methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 1-(3-Iodo-4-Methoxybenzoyl)Prolinate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR) to ensure it meets the stringent requirements for pharmaceutical R&D. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept in a well-ventilated area and protected from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.