Description

5'-Hydroxy-Spiro[Cyclopropane-1,1'-[1H]Isoindol]-3'(2'H)-One is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic and isoindolone scaffold. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for synthesizing novel bioactive molecules. It is primarily targeted at pharmaceutical R&D teams and fine chemical manufacturers engaged in developing new therapeutic agents, particularly in areas requiring complex heterocyclic frameworks.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates targeting central nervous system (CNS) disorders, inflammation, or oncology.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of targeted protein degradation therapeutics.
• Chemical Biology Probes: Utilized in the development of tool compounds for investigating biological pathways and target validation.
• Fine Chemical Synthesis: Employed in multi-step organic syntheses to introduce complex spirocyclic motifs into target molecules.
• Contract Research & Manufacturing (CRAM): Supplied to organizations offering custom synthesis and process development services for the pharmaceutical industry.

Basic Information

Item	Details
Product Name	5'-Hydroxy-Spiro[Cyclopropane-1,1'-[1H]Isoindol]-3'(2'H)-One
CAS No.	1007455-36-8
Molecular Formula	C10H9NO2
Molecular Weight	175.18 g/mol
Synonyms	5'-Hydroxyspiro[cyclopropane-1,1'-isoindol]-3'(2'H)-one; 5'-Hydroxy-1'H-spiro[cyclopropane-1,2'-isoindol]-3'(3a'H)-one; 5'-Hydroxy-2,3-dihydrospiro[cyclopropane-1,1'-isoindol]-3'-one; Spiro[cyclopropane-1,1'-isoindol]-3'(2'H)-one, 5'-hydroxy-; 1007455-36-8; 5'-OH-Spirocyclopropane-isoindolone
EINECS	Contact for details

Quality Control

Our 5'-Hydroxy-Spiro[Cyclopropane-1,1'-[1H]Isoindol]-3'(2'H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with data from HPLC, NMR, and MS, supporting its use in regulated research environments. Specifications are designed to meet the stringent requirements of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound may be light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.