Description

1-[5-(Trifluoromethyl)Pyridin-2-Yl]-1H-Pyrazole-3-Carboxylic Acid is a high-value, multifunctional heterocyclic building block featuring a pyrazole core linked to a trifluoromethyl-substituted pyridine ring. This compound matters for its role as a critical intermediate in the synthesis of advanced pharmaceutical agents and agrochemicals, where its unique trifluoromethyl group enhances metabolic stability and bioavailability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas like oncology, inflammation, and central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity of the pyrazole and pyridine motifs.
• Ligand & Catalyst Development: Serves as a precursor for designing specialized ligands in coordination chemistry and catalysis for asymmetric synthesis.
• Material Science Research: Employed in the synthesis of organic electronic materials and metal-organic frameworks (MOFs) due to its rigid, conjugated structure.
• Custom Synthesis & Contract Manufacturing: A vital building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	1-[5-(Trifluoromethyl)Pyridin-2-Yl]-1H-Pyrazole-3-Carboxylic Acid
CAS No.	1006962-72-6
Molecular Formula	C10H6F3N3O2
Molecular Weight	257.17 g/mol
Synonyms	1-[5-(Trifluoromethyl)-2-pyridinyl]-1H-pyrazole-3-carboxylic acid; 1-(5-(Trifluoromethyl)pyridin-2-yl)-1H-pyrazole-3-carboxylic acid; 2-Pyridinecarboxylic acid, 5-(trifluoromethyl)-, (3-pyrazolyl)amide derivative; 1H-Pyrazole-3-carboxylic acid, 1-[5-(trifluoromethyl)-2-pyridinyl]-; 1006962-72-6; 1-(5-Trifluoromethyl-pyridin-2-yl)-1H-pyrazole-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of 1-[5-(Trifluoromethyl)Pyridin-2-Yl]-1H-Pyrazole-3-Carboxylic Acid adheres to stringent quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure compliance with exacting customer specifications and industry standards. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee supply reliability and batch-to-batch consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.