Description

n-Ethyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Picolinamide is a high-purity, advanced pharmaceutical intermediate and building block featuring a pinacol boronate ester group. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl and heterobiaryl structures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of novel active pharmaceutical ingredients (APIs), particularly for oncology and central nervous system (CNS) targets.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, especially those containing pyridine and biaryl motifs.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds between aryl/heteroaryl halides and the boronate ester group under palladium catalysis.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to optimize lead compounds.
• Chemical Biology Probes: Serves as a precursor for creating labeled molecules or probes used to study biological pathways and target engagement.
• Agrochemical Synthesis: Potential intermediate in the development of advanced crop protection agents with specific activity.
• Material Science: Can be incorporated into the synthesis of organic electronic materials, such as ligands for OLEDs or conductive polymers.

Basic Information

Item	Details
Product Name	n-Ethyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Picolinamide
CAS No.	1006876-28-3
Molecular Formula	C16H25BN2O3
Molecular Weight	304.20 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-ethylpicolinamide; 2-Pyridinecarboxamide, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-ethyl-; N-Ethyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)picolinamide; 5-(Pinacolatoboryl)-N-ethylpicolinamide; 5-Borono-N-ethylpicolinamide pinacol ester; CAS 1006876-28-3
EINECS	Contact for details

Quality Control

Our n-Ethyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Picolinamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ISO standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.