Description

1-(1-Ethyl-5-Methyl-1H-Pyrazol-4-Yl)-4,4-Difluorobutane-1,3-Dione is a high-value, fluorinated pyrazole derivative serving as a critical synthetic intermediate. This compound matters for its role in constructing complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs) and advanced agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate difluorinated β-diketone motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the difluorinated moiety can enhance biological activity and environmental stability.
• Ligand Precursor: Serves as a precursor for the preparation of specialized chelating ligands used in catalysis and material science.
• Advanced Material Research: Employed in the development of organic electronic materials and fluorinated polymers with unique properties.
• Chemical Biology Probe Development: Utilized to create fluorinated analogs of natural products or bioactive molecules for structure-activity relationship (SAR) studies.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects requiring precise fluorination at the β-diketone position.

Basic Information

Product Name	1-(1-Ethyl-5-Methyl-1H-Pyrazol-4-Yl)-4,4-Difluorobutane-1,3-Dione
CAS No.	1005613-67-1
Molecular Formula	C₁₀H₁₂F₂N₂O₂
Molecular Weight	230.21 g/mol
Synonyms	4,4-Difluoro-1-(1-ethyl-5-methyl-1H-pyrazol-4-yl)butane-1,3-dione; 1-(1-Ethyl-5-methyl-1H-pyrazol-4-yl)-4,4-difluorobutane-1,3-dione; 4,4-Difluoro-1-(1-ethyl-5-methylpyrazol-4-yl)butane-1,3-dione; 1-(1-Ethyl-5-methyl-1H-pyrazol-4-yl)-4,4-difluoro-1,3-butanedione; Difluorinated Pyrazole Diketone; Ethyl Methyl Pyrazole Difluorodiketone
EINECS	Contact for details

Quality Control

Our 1-(1-Ethyl-5-Methyl-1H-Pyrazol-4-Yl)-4,4-Difluorobutane-1,3-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring traceability and reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent moisture uptake and potential decomposition. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.