Description

2-Bromo-5-Fluoroisonicotinaldehyde is a high-purity halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its bifunctional reactivity, offering both a bromo substituent for cross-coupling reactions and an aldehyde group for condensation and cyclization. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and complex heterocyclic compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging its halogenated pyridine core.
• Ligand Synthesis: Serves as a starting material for creating complex chelating ligands used in catalysis and material science.
• Material Science: Employed in the research and production of advanced organic electronic materials and functional polymers.
• Cross-Coupling Reactions: The bromine atom is amenable to Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Heterocyclic Chemistry: The aldehyde functionality is utilized in the construction of diverse heterocyclic scaffolds like imidazoles, pyrazoles, and quinolines.

Basic Information

Product Name	2-Bromo-5-Fluoroisonicotinaldehyde
CAS No.	1005291-43-9
Molecular Formula	C6H3BrFNO
Molecular Weight	204.00 g/mol
Synonyms	5-Fluoro-2-bromoisonicotinaldehyde; 2-Bromo-5-fluoropyridine-4-carboxaldehyde; 4-Pyridinecarboxaldehyde, 2-bromo-5-fluoro-; 2-Bromo-5-fluoro-4-formylpyridine; 2-Bromo-5-fluoro-4-pyridinecarboxaldehyde; 1005291-43-9
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-5-Fluoroisonicotinaldehyde is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and storage should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.