Description

(3R)-tert-Butyl 1-(5-Aminopyridin-2-Yl)Pyrrolidin-3-Ylcarbamate is a high-purity chiral intermediate featuring a protected amine and a pyrrolidine-pyridine scaffold. This compound is of significant value for its role in the synthesis of complex, biologically active molecules, particularly in pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists working on novel therapeutics, including kinase inhibitors and other small-molecule drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of active pharmaceutical ingredients (APIs) for preclinical and clinical studies.
• Medicinal Chemistry Research: Used in the design and construction of novel chemical libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Kinase Inhibitor Development: Serves as a core scaffold or precursor in the development of targeted therapies, particularly for oncology and inflammatory diseases.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the efficient, large-scale production of candidate drugs.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis organizations (CSOs) and CDMOs producing specialized compounds for clients.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis and chemical biology.

Basic Information

Product Name	(3R)-tert-Butyl 1-(5-Aminopyridin-2-Yl)Pyrrolidin-3-Ylcarbamate
CAS No.	1004621-13-9
Molecular Formula	C14H22N4O2
Molecular Weight	278.35 g/mol
Synonyms	tert-Butyl (3R)-1-(5-amino-2-pyridinyl)-3-pyrrolidinylcarbamate; (R)-tert-Butyl 1-(5-aminopyridin-2-yl)pyrrolidin-3-ylcarbamate; 1-(5-Aminopyridin-2-yl)-N-Boc-(R)-3-aminopyrrolidine; Carbamic acid, N-[(3R)-1-(5-amino-2-pyridinyl)-3-pyrrolidinyl]-, 1,1-dimethylethyl ester; BOC-(R)-1-(5-Amino-pyridin-2-yl)-pyrrolidin-3-yl-amine
EINECS	Contact for details

Quality Control

Our (3R)-tert-Butyl 1-(5-Aminopyridin-2-Yl)Pyrrolidin-3-Ylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure enantiomeric purity and identity confirmation by NMR and mass spectrometry. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, impurity profiles, and physical data to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.