Description

Ethyl 2-(4-Bromophenyl)-2,2-Difluoroacetate is a high-purity fluorinated organic building block of significant interest in advanced chemical synthesis. This compound matters as a versatile intermediate for introducing difluoroacetate and bromophenyl motifs into complex molecular architectures, enabling the development of novel materials and active compounds. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries for constructing next-generation products.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring difluoromethyl or aryl bromide functional groups.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the difluoroacetate moiety can enhance biological activity and stability.
• Liquid Crystal & OLED Material Precursor: Serves as a critical starting material for synthesizing fluorinated aromatic compounds used in electronic displays and organic light-emitting diodes.
• Cross-Coupling Reactions: The bromophenyl group makes it an excellent substrate for Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to create complex biaryl systems.
• Fluorine Chemistry Research: An essential reagent for academic and industrial research exploring new methodologies in fluoroorganic chemistry.
• Polymer Modification: Used to incorporate fluorine atoms into polymer backbones or side chains to alter material properties like chemical resistance, thermal stability, and surface energy.

Basic Information

Item	Details
Product Name	Ethyl 2-(4-Bromophenyl)-2,2-Difluoroacetate
CAS No.	1004305-97-8
Molecular Formula	C10H9BrF2O2
Molecular Weight	279.08 g/mol
Synonyms	Ethyl 4-Bromo-α,α-difluorophenylacetate; 2-(4-Bromophenyl)-2,2-difluoroacetic Acid Ethyl Ester; Ethyl (4-Bromophenyl)difluoroacetate; Difluoro(4-bromophenyl)acetic Acid Ethyl Ester; 1004305-97-8; Ethyl α,α-Difluoro-4-bromophenylacetate; 4-Bromo-α,α-difluorobenzeneacetic Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Our Ethyl 2-(4-Bromophenyl)-2,2-Difluoroacetate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency meet the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong acids and organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.