Description

3-Bromo-2-Fluoro-4-Iodo-6-Picoline is a high-purity, multi-halogenated pyridine derivative designed for advanced synthetic chemistry. This compound serves as a critical versatile building block for constructing complex molecular architectures, particularly in pharmaceutical and agrochemical research. It is essential for researchers and process chemists in the life sciences and material science sectors who require precise halogen substitution patterns for structure-activity relationship (SAR) studies and lead optimization.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for molecules targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its halogenated structure for bioactivity.
• Ligand Synthesis: Serves as a starting material for creating sophisticated ligands in catalysis and coordination chemistry.
• Material Science: Employed in the development of organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors.
• Cross-Coupling Reactions: An excellent substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) due to the presence of bromo and iodo substituents.
• Chemical Biology: Utilized as a probe or tag in bioconjugation and the development of molecular imaging agents.

Basic Information

Product Name	3-Bromo-2-Fluoro-4-Iodo-6-Picoline
CAS No.	1003711-61-2
Molecular Formula	C6H4BrFIN
Molecular Weight	315.91 g/mol
Synonyms	3-Bromo-2-fluoro-4-iodo-6-methylpyridine; 2-Fluoro-3-bromo-4-iodo-6-picoline; 6-Methyl-3-bromo-2-fluoro-4-iodopyridine; 4-Iodo-3-bromo-2-fluoro-6-methylpyridine; 3-Bromo-2-fluoro-4-iodo-6-picoline; 2-Fluoro-3-bromo-4-iodo-6-methylpyridine
EINECS	Contact for details

Quality Control

Our 3-Bromo-2-Fluoro-4-Iodo-6-Picoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing including HPLC, GC, NMR, and mass spectrometry to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring research and cGMP standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is between 2°C and 8°C for long-term stability. The compound is light-sensitive and should be handled under an inert atmosphere when appropriate to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.