Description

2-Chloro-5-Fluoro-3-Nitro-4-Picoline is a high-purity, multi-functional heterocyclic building block of significant importance in advanced organic synthesis. Its unique halogenated and nitrated pyridine core makes it a critical intermediate for constructing complex molecular architectures. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in the synthesis of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Serves as a versatile building block for creating novel herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science Research: Used in the development of advanced organic electronic materials, ligands for catalysis, and specialty polymers.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new chemical reactions and synthesizing complex heterocyclic compounds.
• Custom Synthesis: An essential starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	2-Chloro-5-Fluoro-3-Nitro-4-Picoline
CAS No.	1003711-51-0
Molecular Formula	C6H4ClFN2O2
Molecular Weight	190.56 g/mol
Synonyms	4-Picoline, 2-chloro-5-fluoro-3-nitro-; 2-Chloro-5-fluoro-3-nitropyridine, 4-methyl-; 3-Nitro-2-chloro-5-fluoro-4-methylpyridine; 4-Methyl-2-chloro-5-fluoro-3-nitropyridine; 2-Chloro-5-fluoro-3-nitro-4-methylpyridine; 1003711-51-0; 2-Chloro-5-fluoro-3-nitro-4-picoline
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Fluoro-3-Nitro-4-Picoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.