Description

tert-Butyl 2-(((Trifluoromethyl)Sulfonyl)Oxy)-8,9-Dihydro-5H-Pyrido[2,3-D]Azepine-7(6H)-Carboxylate (Wx141097) is a high-value, advanced pharmaceutical intermediate featuring a reactive trifluoromethanesulfonate (triflate) ester group. This compound is critical for enabling efficient cross-coupling reactions, particularly in the synthesis of complex nitrogen-containing heterocycles. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex polycyclic nitrogen heterocycles with potential therapeutic applications.
• Cross-Coupling Reactions: Serves as an excellent electrophile in palladium-catalyzed reactions (e.g., Suzuki, Stille, Negishi) for introducing the pyridoazepine scaffold into target molecules.
• Medicinal Chemistry Research: Enables rapid structure-activity relationship (SAR) exploration and library synthesis for drug discovery programs targeting CNS disorders, oncology, and inflammation.
• Agrochemical Development: Used in the research and synthesis of novel crop protection agents and pesticides.
• Chemical Biology Probes: Facilitates the creation of labeled compounds and molecular probes for studying biological pathways.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of candidate drugs.

Basic Information

Product Name	tert-Butyl 2-(((Trifluoromethyl)Sulfonyl)Oxy)-8,9-Dihydro-5H-Pyrido[2,3-D]Azepine-7(6H)-Carboxylate (Wx141097)
CAS No.	1003589-97-6
Molecular Formula	C16H19F3N2O5S
Molecular Weight	408.39 g/mol
Synonyms	7-(tert-Butoxycarbonyl)-2-(((trifluoromethyl)sulfonyl)oxy)-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepine; tert-Butyl 2-(trifluoromethanesulfonyloxy)-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepine-7-carboxylate; 2-Triflyloxy-7-Boc-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepine; Wx141097; BOC-protected Pyridoazepine Triflate; 7-Boc-2-OTf-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepine
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-(((Trifluoromethyl)Sulfonyl)Oxy)-8,9-Dihydro-5H-Pyrido[2,3-D]Azepine-7(6H)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity suitable for sensitive coupling reactions. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.