Description

tert-Butyl 2-Hydroxy-8,9-Dihydro-5H-Pyrido[2,3-D]Azepine-7(6H)-Carboxylate is a high-purity, advanced pharmaceutical intermediate of significant commercial interest. This compound serves as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders. It is essential for research and development chemists, process scale-up engineers, and manufacturers within the global pharmaceutical and fine chemical industries seeking reliable, high-quality intermediates for innovative drug development pipelines.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel therapeutic agents, particularly for neurological and psychiatric conditions.
• API Synthesis: Used in multi-step organic synthesis to construct complex molecular architectures found in potential drug candidates.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry & Scale-Up: Employed in the development and optimization of robust, scalable manufacturing routes for target molecules under Good Manufacturing Practice (GMP) standards.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and development services for the pharmaceutical industry.
• Reference Standard: Can be utilized as a high-purity analytical standard for method development and quality control in API production.

Basic Information

Product Name	tert-Butyl 2-Hydroxy-8,9-Dihydro-5H-Pyrido[2,3-D]Azepine-7(6H)-Carboxylate
CAS No.	1003589-96-5
Molecular Formula	C15H20N2O3
Molecular Weight	276.33 g/mol
Synonyms	7-(tert-Butoxycarbonyl)-2-hydroxy-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepine; 2-Hydroxy-8,9-dihydro-5H-pyrido[2,3-d]azepine-7(6H)-carboxylic acid tert-butyl ester; tert-Butyl 2-hydroxy-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepine-7-carboxylate; 5H-Pyrido[2,3-d]azepine-7(6H)-carboxylic acid, 8,9-dihydro-2-hydroxy-, 1,1-dimethylethyl ester; 1003589-96-5; tert-Butyl 2-hydroxy-5,6,8,9-tetrahydro-4H-pyrido[2,3-d]azepine-7-carboxylate
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-Hydroxy-8,9-Dihydro-5H-Pyrido[2,3-D]Azepine-7(6H)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS), to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.