Description

Ethyl 2-Chloro-6-Ethoxynicotinate is a high-purity, synthetically valuable nicotinate derivative. This compound serves as a critical pharmaceutical intermediate and versatile organic building block for advanced chemical synthesis. It is primarily required by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex heterocyclic molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing functionalized pyridine cores.
• Agrochemical Synthesis: Building block for developing novel herbicides, insecticides, and fungicides with enhanced efficacy.
• Fine Chemical Production: Used in the manufacture of specialty chemicals, dyes, and functional materials.
• Research & Development: Essential reagent in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Cross-Coupling Reactions: Serves as a substrate in palladium-catalyzed reactions like Suzuki-Miyaura or Buchwald-Hartwig amination for C-C and C-N bond formation.
• Ligand and Catalyst Development: Useful for synthesizing novel chelating ligands and organocatalysts.

Basic Information

Product Name	Ethyl 2-Chloro-6-Ethoxynicotinate
CAS No.	1003578-20-8
Molecular Formula	C10H12ClNO3
Molecular Weight	229.66 g/mol
Synonyms	2-Chloro-6-ethoxy-3-pyridinecarboxylic acid ethyl ester; Ethyl 2-chloro-6-ethoxypyridine-3-carboxylate; 3-Pyridinecarboxylic acid, 2-chloro-6-ethoxy-, ethyl ester; 6-Ethoxy-2-chloronicotinic acid ethyl ester; 2-Chloro-6-ethoxynicotinic acid ethyl ester; Ethyl 6-ethoxy-2-chloronicotinate
EINECS	Contact for details

Quality Control

Our Ethyl 2-Chloro-6-Ethoxynicotinate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for each lot. We support cGMP compliance for pharmaceutical applications and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound may be light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.