Description

Remimazolam Benzenesulfonate is a novel, ultra-short-acting benzodiazepine derivative used as a sedative and anesthetic agent. Its primary value lies in its rapid onset of action and predictable, quick recovery profile, making it a significant advancement in procedural sedation and general anesthesia. This product is essential for pharmaceutical manufacturers and research institutions developing next-generation intravenous sedatives, particularly for use in hospital settings, outpatient procedures, and intensive care.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the key component in injectable sedative and anesthetic formulations.
• Procedural Sedation: For short-duration medical procedures such as colonoscopy, bronchoscopy, and cardiac catheterization.
• General Anesthesia Induction & Maintenance: Used in operating rooms for initiating and sustaining anesthesia, often in combination with other agents.
• Intensive Care Unit (ICU) Sedation: For sedating mechanically ventilated patients due to its titratability and rapid offset.
• Research & Development: Serves as a critical reference standard and raw material in pharmacological studies and new drug development.
• Formulation Development: Used in the development of generic and innovative dosage forms, including lyophilized powders for injection.

Basic Information

Product Name	Remimazolam Benzenesulfonate
CAS No.	1001415-66-2
Molecular Formula	C21H19BrN4O2 • C6H6O3S
Molecular Weight	583.44 g/mol (as benzenesulfonate salt)
Synonyms	Remimazolam Besylate; CNS 7056; ONO-2745; Methyl 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a][1,4]benzodiazepin-4-yl]propanoate benzenesulfonate; Remimazolam benzene sulfonate; Remimazolam (as besilate); Remimazolam besilate; BYFAVO™ (brand name for formulated product)
EINECS	Contact for details

Quality Control

Our Remimazolam Benzenesulfonate is manufactured under strict quality management systems. We provide material that meets high-purity standards suitable for pharmaceutical development and manufacturing. A comprehensive Certificate of Analysis (COA) is supplied with each batch, detailing key parameters such as assay, related substances, residual solvents, and identity confirmation. Our quality commitment ensures compliance with cGMP and ICH guidelines for API manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Individual impurity: NMT 0.5% Total impurities: NMT 2.0%
Water Content (KF)	NMT 5.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	NMT 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.