Description

Carbamic Acid tert-Butyl Ester is a versatile chemical intermediate of significant importance in advanced organic synthesis. Its primary value lies in its role as a key building block for the introduction of the tert-butoxycarbonyl (Boc) protecting group, a cornerstone in peptide and pharmaceutical manufacturing. This compound is essential for researchers and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity intermediates for complex molecule assembly.

Application

• Boc-Protecting Agent: Primary use as a reagent for introducing the acid-labile tert-butoxycarbonyl (Boc) protecting group onto amines in peptide and small molecule synthesis.
• Pharmaceutical Intermediates: Critical building block in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for cancer therapies and neurological drugs.
• Peptide Synthesis: Enables the sequential assembly of peptide chains by protecting amino groups, preventing unwanted side reactions during coupling steps.
• Agrochemical Development: Used in the research and production of advanced herbicides, fungicides, and plant growth regulators.
• Custom Synthesis & R&D: Serves as a fundamental starting material for contract research organizations (CROs) and academic laboratories exploring novel organic compounds.
• Material Science: Potential monomer or modifier in the synthesis of specialized polymers with tailored properties.

Basic Information

Product Name	Carbamic Acid tert-Butyl Ester
CAS No.	1001414-20-5
Molecular Formula	C5H11NO2
Molecular Weight	117.15 g/mol
Synonyms	tert-Butyl carbamate; Boc-NH2; N-Boc-amine; (tert-Butoxy)formamide; N-(tert-Butoxycarbonyl)amine; 2-Methyl-2-propanyl carbamate; BOC-amine; tert-Butoxycarbamic acid
EINECS	Contact for details

Quality Control

Our Carbamic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) are provided with every shipment, detailing all relevant specifications. We adhere to cGMP standards where applicable to meet the stringent requirements of our pharmaceutical and research clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	85 - 89 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.