Description

1H-Pyrrolo[2,3-B]Pyridine-5-Carboxylic Acid, 3-Iodo-1-(Phenylsulfonyl)-, Methyl Ester is a high-purity, functionalized heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key synthetic intermediate in the development of novel pharmacologically active molecules, particularly in medicinal chemistry. Pharmaceutical R&D and fine chemical synthesis laboratories need this specialized chemical to construct complex molecular architectures for drug discovery programs targeting various therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel small-molecule drug candidates, particularly for kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes due to its versatile functional groups (iodo, sulfonyl, ester).
• Chemical Biology Probe Development: Employed in the creation of chemical probes to study biological pathways and protein functions.
• Agrochemical Synthesis: Potential intermediate in the research and development of new active ingredients for crop protection.
• Material Science Precursor: Can be utilized in the synthesis of organic electronic materials or ligands for catalytic systems.
• Cross-Coupling Reactions: The iodine substituent makes it a valuable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create more complex structures.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine-5-Carboxylic Acid, 3-Iodo-1-(Phenylsulfonyl)-, Methyl Ester
CAS No.	1001414-06-7
Molecular Formula	C15H11IN2O4S
Molecular Weight	442.23 g/mol
Synonyms	Methyl 3-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate; 1H-Pyrrolo[2,3-b]pyridine-5-carboxylic acid, 3-iodo-1-(phenylsulfonyl)-, methyl ester; 3-Iodo-1-tosyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid methyl ester; 1-(Benzenesulfonyl)-3-iodo-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid methyl ester; 1-(Phenylsulfonyl)-3-iodo-1H-pyrrolo[2,3-b]pyridine-5-carboxylate
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine-5-Carboxylic Acid, 3-Iodo-1-(Phenylsulfonyl)-, Methyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory needs in pre-clinical and clinical development stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.