Description

3-Pyridinecarboxamide, n-[(5-Bromo-2-Thienyl)Methyl]-1-[(3,4-Difluorophenyl)Methyl]-1,2-Dihydro-2-Oxo- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound matters for its critical role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular targeting. It is primarily needed by pharmaceutical R&D organizations and contract manufacturing organizations (CMOs) engaged in developing next-generation small-molecule drugs.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) research.
• Medicinal Chemistry Research: Used as a scaffold or building block for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• API Development: Integral in the process development and scale-up stages for new active pharmaceutical ingredients, leveraging its bromo-thienyl and difluorophenyl motifs.
• Biochemical Research: Potential use as a tool compound or inhibitor in enzymatic and receptor-binding assays due to its specific molecular architecture.
• Contract Synthesis: Supplied to custom synthesis and fine chemical manufacturers for the production of specialized, high-value compounds for clinical trials.

Basic Information

Product Name	3-Pyridinecarboxamide, n-[(5-Bromo-2-Thienyl)Methyl]-1-[(3,4-Difluorophenyl)Methyl]-1,2-Dihydro-2-Oxo-
CAS No.	1001413-88-2
Molecular Formula	C18H13BrF2N2O2S
Molecular Weight	439.28 g/mol
Synonyms	N-[(5-Bromo-2-thienyl)methyl]-1-[(3,4-difluorophenyl)methyl]-1,2-dihydro-2-oxo-3-pyridinecarboxamide; 1-[(3,4-Difluorobenzyl)]-N-[(5-bromothiophen-2-yl)methyl]-2-oxo-1,2-dihydropyridine-3-carboxamide; 1001413-88-2; (5-Bromo-2-thienyl)Methyl Amide of 1-[(3,4-Difluorophenyl)Methyl]-2-oxo-1,2-dihydro-3-pyridinecarboxylic Acid
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for advanced pharmaceutical intermediates. Each batch is characterized and controlled using advanced analytical techniques including HPLC, GC, NMR, and MS to confirm identity, purity, and impurity profiles. Certificates of Analysis (COA) with full analytical data are available upon request. Our quality system supports development under cGMP guidelines as required for pre-clinical and clinical stage materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.