Description

(S)-4,4-Dimethyl-Pyrrolidine-1,2-Dicarboxylic Acid 1-tert-Butyl Ester 2-Ethyl Ester is a high-purity chiral building block and protected amino acid derivative essential for advanced organic synthesis. This compound matters as a critical intermediate in the development of novel pharmaceuticals, particularly for constructing complex molecules with defined stereochemistry. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for applications in drug discovery, process development, and the synthesis of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs.
• Peptidomimetic Synthesis: Used in the construction of peptide analogs and peptidomimetics for therapeutic applications.
• Asymmetric Catalysis: Serves as a precursor or ligand in the development of asymmetric catalytic systems.
• Agrochemical Research: Intermediate in the synthesis of chiral active ingredients for crop protection products.
• Academic & R&D: A valuable reagent for university and corporate research laboratories exploring new synthetic methodologies.
• Custom Synthesis: Starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke fine chemicals.

Basic Information

Product Name	(S)-4,4-Dimethyl-Pyrrolidine-1,2-Dicarboxylic Acid 1-tert-Butyl Ester 2-Ethyl Ester
CAS No.	1001353-86-1
Molecular Formula	C15H27NO4
Molecular Weight	285.38 g/mol
Synonyms	(S)-1-(tert-Butoxycarbonyl)-4,4-dimethylpyrrolidine-2-carboxylic acid ethyl ester; (S)-1-Boc-4,4-dimethylproline ethyl ester; (S)-Ethyl 1-Boc-4,4-dimethylpyrrolidine-2-carboxylate; (S)-4,4-Dimethyl-1-Boc-proline ethyl ester; (S)-1-tert-Butyl 2-ethyl 4,4-dimethylpyrrolidine-1,2-dicarboxylate; (S)-Boc-4,4-dimethyl-Pro-OEt; (S)-tert-Butyl 2-(ethoxycarbonyl)-4,4-dimethylpyrrolidine-1-carboxylate
EINECS	Contact for details

Quality Control

Our (S)-4,4-Dimethyl-Pyrrolidine-1,2-Dicarboxylic Acid 1-tert-Butyl Ester 2-Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity, chiral integrity, and lot-to-lot consistency. Certificates of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.