Description

1H-Pyrrolo[2,3-B]Pyridine, 5-Methyl-1-(Phenylsulfonyl)- is a high-purity, advanced pharmaceutical intermediate belonging to the fused pyrrolopyridine class of heterocyclic compounds. This compound is a critical building block in modern medicinal chemistry, valued for its role in constructing complex molecular architectures with targeted biological activity. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new active pharmaceutical ingredients (APIs).
• Kinase Inhibitor Synthesis: Serves as a core scaffold for the construction of potent and selective kinase inhibitors, a major class of oncology drugs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns to improve drug potency and selectivity.
• Biochemical Probe Development: Employed in creating tool compounds for investigating specific biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied for custom synthesis projects requiring this specific, high-value chemical entity.
• Academic Research: Utilized in university and institutional labs for novel heterocyclic chemistry and methodology development.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine, 5-Methyl-1-(Phenylsulfonyl)-
CAS No.	1001070-50-3
Molecular Formula	C14H12N2O2S
Molecular Weight	272.32 g/mol
Synonyms	5-Methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 1-(Phenylsulfonyl)-5-methyl-1H-pyrrolo[2,3-b]pyridine; 5-Methyl-1-tosyl-1H-pyrrolo[2,3-b]pyridine (common); 1H-Pyrrolo[2,3-b]pyridine, 5-methyl-1-(phenylsulfonyl)-; 1001070-50-3; 5-Methyl-1-(benzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine; N-(Phenylsulfonyl)-5-methyl-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine, 5-Methyl-1-(Phenylsulfonyl)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and pre-clinical development stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound should be kept under an inert atmosphere for long-term storage to maintain stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.