Description

2-(Trimethylsilyl)Ethyl 3-Nitro-1H-1,2,4-Triazole-1-Carboxylate is a specialized, high-value organosilicon-protected intermediate used in advanced organic synthesis. This compound is critical for researchers and manufacturers requiring precise, stepwise construction of complex molecules, particularly in pharmaceutical development. Its primary value lies in its role as a protected triazole building block, enabling the controlled introduction of the 3-nitro-1,2,4-triazole pharmacophore under mild conditions. Key industries that utilize this intermediate include pharmaceutical R&D, agrochemical synthesis, and materials science for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key protected precursor in the synthesis of novel drug candidates, particularly those containing the 1,2,4-triazole core, which is prevalent in compounds with antimicrobial, antifungal, and anticancer activities.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, where the nitro-triazole moiety can contribute to biological activity.
• Peptide Mimetics & Bioconjugation: The 2-(trimethylsilyl)ethyl (TMSE) protecting group allows for its use in solid-phase peptide synthesis (SPPS) and the creation of peptide-triazole hybrids or bioconjugates.
• Ligand & Catalyst Development: Acts as a starting material for synthesizing specialized ligands and metal-organic complexes used in catalysis.
• Materials Science Research: Employed in the development of energetic materials, polymers, or metal-organic frameworks (MOFs) with specific functional groups.
• Chemical Biology Probes: Useful for creating activity-based probes or labeled compounds for studying biological pathways and enzyme functions.

Basic Information

Product Name	2-(Trimethylsilyl)Ethyl 3-Nitro-1H-1,2,4-Triazole-1-Carboxylate
CAS No.	1001067-09-9
Molecular Formula	C8H14N4O4Si
Molecular Weight	258.31 g/mol
Synonyms	3-Nitro-1H-1,2,4-triazole-1-carboxylic acid 2-(trimethylsilyl)ethyl ester; 2-(Trimethylsilyl)ethyl 3-nitro-1,2,4-triazole-1-carboxylate; TMSE 3-Nitro-1,2,4-triazole-1-carboxylate; 1-[[2-(Trimethylsilyl)ethoxy]carbonyl]-3-nitro-1,2,4-triazole; 1001067-09-9; 3-Nitro-1,2,4-triazol-1-yl 2-(trimethylsilyl)ethyl carbonate
EINECS	Contact for details

Quality Control

Our 2-(Trimethylsilyl)Ethyl 3-Nitro-1H-1,2,4-Triazole-1-Carboxylate is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive synthetic applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and NMR for structural confirmation. We provide detailed Certificates of Analysis (COA) with every shipment, documenting key specifications. Our quality systems support development under cGMP guidelines for pharmaceutical research, and we are committed to meeting the stringent requirements of global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.