Description

2-Chloropyridine-4-Sulfonyl Chloride is a high-purity, reactive organosulfur compound that serves as a critical building block in advanced chemical synthesis. Its dual functionality as a sulfonyl chloride and a halogenated heterocycle makes it an indispensable reagent for introducing the 2-chloropyridine-4-sulfonyl moiety into target molecules. This intermediate is primarily sought by research and development teams in the pharmaceutical and agrochemical sectors for the creation of novel active ingredients, including potential enzyme inhibitors and receptor modulators.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for sulfonamide-based drugs targeting various therapeutic areas.
• Agrochemical Synthesis: Used in the development of new-generation herbicides, fungicides, and insecticides, where the pyridine-sulfonyl scaffold contributes to biological activity.
• Chemical Research & Development: A versatile reagent in medicinal chemistry for structure-activity relationship (SAR) studies and the construction of compound libraries for high-throughput screening.
• Material Science: Potential monomer or cross-linking agent in the development of specialized polymers and functional materials.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke intermediates under cGMP conditions where required.

Basic Information

Product Name	2-Chloropyridine-4-Sulfonyl Chloride
CAS No.	1000933-25-4
Molecular Formula	C5H3Cl2NO2S
Molecular Weight	212.05 g/mol
Synonyms	4-Pyridinesulfonyl chloride, 2-chloro-; 2-Chloro-4-pyridinesulfonyl chloride; 2-Chloro-4-pyridylsulfonyl chloride; 2-Chloropyridine-4-sulfonic acid chloride; 2-Chloroisonicotinesulfonyl chloride; 1000933-25-4; 2-Chloro-4-sulfonylchloridopyridine
EINECS	Contact for details

Quality Control

Every batch of 2-Chloropyridine-4-Sulfonyl Chloride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA), including results from HPLC, NMR, and other relevant analytical techniques, is supplied with each shipment to guarantee identity, purity, and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.