Description

2-o-(p-Nitrophenyl)-4,7,8,9-Tetra-o-Acetyl-α-D-n-Acetylglycolylneuraminic Acid Methyl Ester is a sophisticated, high-purity sialic acid derivative, serving as a critical advanced intermediate in organic synthesis and pharmaceutical research. Its value lies in its role as a key building block for the development of novel glycoconjugates, sialidase inhibitors, and other bioactive molecules targeting viral and bacterial infections. This compound is essential for research and development teams in the pharmaceutical, biotechnology, and fine chemical sectors who require reliable, high-quality intermediates for complex synthetic pathways.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel sialidase inhibitors for antiviral and antibacterial drug discovery.
• Glycobiology Research: Used as a building block for constructing complex oligosaccharides, glycopeptides, and glycolipids to study cell-cell recognition and signaling.
• Probe Development: The p-nitrophenyl group makes it a useful substrate or intermediate for developing chromogenic or fluorogenic enzyme activity assays.
• Chemical Biology Tool: Employed in the synthesis of sialic acid analogs to investigate metabolic pathways and enzyme mechanisms.
• Fine Chemical Synthesis: Serves as a specialized intermediate for custom synthesis and contract manufacturing of high-value target molecules.

Basic Information

Product Name	2-o-(p-Nitrophenyl)-4,7,8,9-Tetra-o-Acetyl-α-D-n-Acetylglycolylneuraminic Acid Methyl Ester
CAS No.	1000890-49-2
Molecular Formula	C32H40N2O19
Molecular Weight	756.67 g/mol
Synonyms	2-O-(4-Nitrophenyl)-4,7,8,9-tetra-O-acetyl-N-acetyl-α-D-neuraminic acid methyl ester; Methyl (5-acetamido-4,7,8,9-tetra-O-acetyl-2-O-(4-nitrophenyl)-3,5-dideoxy-D-glycero-α-D-galacto-non-2-ulopyranosid)onate; p-Nitrophenyl sialic acid derivative; Sialic Acid Methyl Ester Derivative; Neu5Ac Derivative; Glycolylneuraminic Acid Ester; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and purity for research and development applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We employ advanced analytical techniques including HPLC, NMR, and MS to verify the chemical structure and meet the exacting standards required for pharmaceutical-grade intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light). For long-term storage, consider storing under inert atmosphere at lower temperatures (-20°C) to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.