Description

6-Chloro-5-Azaindole-3-Carboxylic Acid is a high-purity, heterocyclic carboxylic acid building block of significant importance in modern pharmaceutical research and development. Its core value lies in its unique molecular scaffold, which serves as a privileged structure for designing novel bioactive compounds, particularly kinase inhibitors and other targeted therapies. This intermediate is essential for medicinal chemists and process development scientists working in pharmaceutical, biotechnology, and fine chemical synthesis sectors.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially in oncology and inflammatory disease research.
• Kinase Inhibitor Development: Serves as a core scaffold in the design and synthesis of potent and selective kinase inhibitors due to the azaindole pharmacophore.
• Chemical Biology Probes: Used in the creation of tool compounds for target validation and pathway analysis in biological systems.
• Process Chemistry & Scale-up: Employed in route scouting and optimization for the commercial-scale production of active pharmaceutical ingredients (APIs).
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and contract research organizations (CROs/CMOs).
• Academic Research: Utilized in university and institutional labs for exploratory synthetic chemistry and medicinal chemistry programs.

Basic Information

Product Name	6-Chloro-5-Azaindole-3-Carboxylic Acid
CAS No.	1000341-67-2
Molecular Formula	C8H5ClN2O2
Molecular Weight	196.59 g/mol
Synonyms	6-Chloro-1H-pyrrolo[3,2-b]pyridine-3-carboxylic acid; 6-Chloro-5-aza-1H-indole-3-carboxylic acid; 6-Chloro-5-azaindole-3-carboxylic acid; 6-Chloro-1H-pyrrolo[3,2-b]pyridine-3-carboxylic acid; 5-Azaindole-3-carboxylic acid, 6-chloro-; 6-Chloro-1H-pyrrolo[3,2-b]pyridine-3-carboxylic acid (9CI)
EINECS	Contact for details

Quality Control

Our 6-Chloro-5-Azaindole-3-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports applications requiring high-purity building blocks for GMP and non-GMP pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.