Description

Methyl 3-{[4-(Trifluoromethyl)Piperidino]Methyl}Benzenecarboxylate is a high-value, synthetically versatile organic intermediate featuring a piperidine scaffold substituted with a trifluoromethyl group. This compound is specifically engineered to serve as a critical building block in advanced pharmaceutical and agrochemical research and development. Its unique structure makes it essential for medicinal chemists and process development scientists working on novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly for central nervous system (CNS) targets, enzyme inhibitors, and receptor modulators.
• Agrochemical Research: Used in developing new-generation pesticides, herbicides, and fungicides where the trifluoromethyl group enhances biological activity and metabolic stability.
• Chemical Biology Probe Synthesis: Serves as a scaffold for creating molecular probes to study biological pathways and protein functions.
• Material Science Applications: Potential monomer or additive for specialty polymers where fluorine incorporation can alter surface properties and stability.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthetic routes and scale-up projects.

Basic Information

Product Name	Methyl 3-{[4-(Trifluoromethyl)Piperidino]Methyl}Benzenecarboxylate
CAS No.	1000339-86-5
Molecular Formula	C15H18F3NO2
Molecular Weight	301.31 g/mol
Synonyms	3-[(4-(Trifluoromethyl)piperidin-1-yl)methyl]benzoic acid methyl ester; Methyl 3-((4-(trifluoromethyl)piperidin-1-yl)methyl)benzoate; 1-[3-(Methoxycarbonyl)benzyl]-4-(trifluoromethyl)piperidine; Benzoic acid, 3-[[4-(trifluoromethyl)-1-piperidinyl]methyl]-, methyl ester
EINECS	Contact for details

Quality Control

Our production of Methyl 3-{[4-(Trifluoromethyl)Piperidino]Methyl}Benzenecarboxylate adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical characterization, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects with material produced under cGMP guidelines as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (HPLC)	≥ 98.0% / ≥ 99.0% (Higher Grades Available)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.