Description

Spiro[4H-1-Benzazepine-4,1'-[2]Cyclopentene]-3'-Carboxylic Acid, 1,2,3,5-Tetrahydro-, Ethyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic and benzazepine fused-ring structure. This compound is of significant value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of next-generation therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of proprietary drug candidates, especially in neurological and psychiatric research.
• Organic Synthesis Building Block: Utilized in medicinal chemistry for constructing complex molecular architectures due to its spirocyclic core.
• Research & Development (R&D): Serves as a standard or investigational material in academic and industrial laboratories for pharmacological studies and route scouting.
• API Manufacturing: Employed in the pilot-scale and commercial-scale production of specific active pharmaceutical ingredients requiring this benzazepine scaffold.

Basic Information

Product Name	Spiro[4H-1-Benzazepine-4,1'-[2]Cyclopentene]-3'-Carboxylic Acid, 1,2,3,5-Tetrahydro-, Ethyl Ester
CAS No.	1000181-36-1
Molecular Formula	C17H19NO2
Molecular Weight	269.34 g/mol
Synonyms	Ethyl 1,2,3,5-tetrahydrospiro[4H-1-benzazepine-4,1'-cyclopentene]-3'-carboxylate; Spiro[cyclopentene-1,4'-1,2,3,5-tetrahydro-4H-1-benzazepine]-3'-carboxylic acid ethyl ester; 1,2,3,5-Tetrahydrospiro[4H-1-benzazepine-4,1'-cyclopentene]-3'-carboxylic acid ethyl ester; Ethyl 1,2,3,5-tetrahydrospiro[1-benzazepine-4,1'-cyclopentene]-3'-carboxylate; CAS 1000181-36-1
EINECS	Contact for details

Quality Control

Our Spiro[4H-1-Benzazepine-4,1'-[2]Cyclopentene]-3'-Carboxylic Acid, 1,2,3,5-Tetrahydro-, Ethyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and manufacturing. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.