Description

(E)-Methyl 3-(4-Chloro-2-(Trifluoromethyl)Phenyl)Acrylate CAS NO 1000052-74-3 is a high-purity, specialized acrylate ester monomer featuring a chlorinated and trifluoromethylated aromatic ring. This compound is a critical pharmaceutical intermediate and advanced material precursor, valued for its unique structural motifs that enable the synthesis of complex molecules. It is primarily sought by R&D and production teams in the pharmaceutical, agrochemical, and functional polymer industries for developing novel active ingredients and specialty polymers.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, leveraging the chloro and trifluoromethyl groups for enhanced bioactivity.
• Functional Polymer Monomer: Serves as a precursor for specialty polymers and coatings, imparting properties like chemical resistance, low surface energy, and thermal stability.
• Liquid Crystal & OLED Material Research: Acts as a core synthon in the development of organic electronic materials and liquid crystal displays (LCDs).
• Cross-coupling Reactions: A versatile substrate in palladium-catalyzed cross-coupling reactions (e.g., Heck, Suzuki) for constructing complex biaryl structures.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D in medicinal chemistry and material science.

Basic Information

Item	Detail
Product Name	(E)-Methyl 3-(4-Chloro-2-(Trifluoromethyl)Phenyl)Acrylate
CAS No.	1000052-74-3
Molecular Formula	C11H8ClF3O2
Molecular Weight	264.63 g/mol
Synonyms	Methyl (E)-3-[4-Chloro-2-(trifluoromethyl)phenyl]acrylate; Methyl (E)-3-(4-Chloro-2-trifluoromethylphenyl)propenoate; (E)-Methyl 3-(4-Chloro-2-(trifluoromethyl)phenyl)-2-propenoate; trans-Methyl 3-(4-Chloro-2-(trifluoromethyl)phenyl)acrylate; 4-Chloro-α-(trifluoromethyl)cinnamic acid methyl ester; Methyl 3-(4-Chloro-2-trifluoromethylphenyl)acrylate; MFCD13191306
EINECS	Contact for details

Quality Control

Our (E)-Methyl 3-(4-Chloro-2-(Trifluoromethyl)Phenyl)Acrylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and GC-MS and NMR for structural confirmation, to ensure it meets the high standards required for pharmaceutical and advanced material applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flames. The container should be kept tightly sealed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0% (Area %)
Isomeric Purity (E/Z Ratio)	≥ 99:1 (E/Z)
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.