Description

tert-Butyl 4-[5-Bromo-3-(Methoxycarbonyl)Pyridin-2-Yl]Piperazine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a functionalized pyridine-piperazine core. This compound matters for its critical role as a versatile building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in medicinal chemistry research and development. Pharmaceutical, agrochemical, and specialty chemical manufacturers need this intermediate for constructing molecules with targeted biological activity, leveraging its reactive bromo and ester functionalities for further derivatization.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns for constructing diverse compound libraries via cross-coupling and amidation reactions.
• Agrochemical Synthesis: Serves as a precursor in the development of new-generation pesticides and herbicides with specific mode-of-action targets.
• Chemical Biology Probes: Utilized in the creation of tagged or labeled molecules for studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scaled-up production under cGMP conditions.
• Academic & Institutional Research: Provides a standardized, high-quality starting material for synthetic methodology development and academic studies.

Basic Information

Product Name	tert-Butyl 4-[5-Bromo-3-(Methoxycarbonyl)Pyridin-2-Yl]Piperazine-1-Carboxylate
CAS No.	1000018-22-3
Molecular Formula	C16H20BrN3O4
Molecular Weight	398.25 g/mol
Synonyms	1-Boc-4-(5-Bromo-3-(methoxycarbonyl)pyridin-2-yl)piperazine; 2-(4-(tert-Butoxycarbonyl)piperazin-1-yl)-5-bromo-3-methoxycarbonylpyridine; tert-Butyl 4-(5-bromo-3-(methoxycarbonyl)pyridin-2-yl)piperazine-1-carboxylate; 5-Bromo-2-(4-(tert-butoxycarbonyl)piperazin-1-yl)nicotinic acid methyl ester; 1000018-22-3; BOC-Piperazine-Pyridine-Br-ester; Methyl 5-bromo-2-(4-(tert-butoxycarbonyl)piperazin-1-yl)nicotinate
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-[5-Bromo-3-(Methoxycarbonyl)Pyridin-2-Yl]Piperazine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with complete batch-specific data are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.