Description

Cyclopropaneacetic Acid, 2,2-Difluoro-3-Methylene- (9Ci) is a specialized fluorinated cyclopropane derivative, a high-value building block prized for its unique strained-ring structure and fluorine atoms. This compound is essential for introducing the cyclopropane motif and fluorine substituents into target molecules, which are critical for modulating the biological activity, metabolic stability, and physicochemical properties of advanced materials. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides, where the fluorinated cyclopropane unit can enhance potency and environmental stability.
• Advanced Material Precursor: Serves as a building block for specialty polymers, liquid crystals, and organic electronic materials requiring specific steric and electronic properties.
• Fluorine Chemistry Research: An important reagent in academic and industrial laboratories studying the effects of fluorination and ring strain on chemical reactivity and molecular conformation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in client-specific, multi-step synthetic routes.

Basic Information

Product Name	Cyclopropaneacetic Acid, 2,2-Difluoro-3-Methylene- (9Ci)
CAS No.	199176-95-9
Molecular Formula	C6H6F2O2
Molecular Weight	148.11 g/mol
Synonyms	2,2-Difluoro-3-methylidenecyclopropane-1-carboxylic acid; 2,2-Difluoro-3-methylenecyclopropanecarboxylic Acid; 3-Methylene-2,2-difluorocyclopropanecarboxylic Acid; 2,2-Difluoro-3-methylenecyclopropaneacetic Acid; (2,2-Difluoro-3-methylidenecyclopropyl)formic acid
EINECS	Contact for details

Quality Control

Our production of Cyclopropaneacetic Acid, 2,2-Difluoro-3-Methylene- (9Ci) adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and GC-MS. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is sensitive to fluoride/strong alkali. Keep away from incompatible materials and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.