Description

Exo-6-Hydroxy-2-Aza-Bicyclo[2.2.1]Heptane-2-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its unique bicyclic structure. This compound is a critical chiral building block for the synthesis of complex active pharmaceutical ingredients (APIs), offering significant value in the development of stereochemically defined drug candidates. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, particularly in the areas of neurology and metabolic diseases.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of complex drug molecules, particularly those targeting the central nervous system.
• Protease Inhibitor Development: Used in research and production of inhibitors for various proteolytic enzymes, leveraging its constrained bicyclic scaffold.
• Peptidomimetic Chemistry: Acts as a rigid, non-natural amino acid analog for constructing conformationally restricted peptides with enhanced metabolic stability.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric transformations to introduce stereogenic centers.
• Medicinal Chemistry Research: Provides a versatile scaffold for structure-activity relationship (SAR) studies in early-stage drug discovery programs.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.

Basic Information

Product Name	Exo-6-Hydroxy-2-Aza-Bicyclo[2.2.1]Heptane-2-Carboxylic Acid tert-Butyl Ester
CAS No.	198835-02-8
Molecular Formula	C11H19NO3
Molecular Weight	213.27 g/mol
Synonyms	(1R,2S,4S,6R)-6-Hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester; tert-Butyl (1R,2S,4S,6R)-6-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate; exo-6-Hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylic acid 1,1-dimethylethyl ester; 2-Azabicyclo[2.2.1]heptane-2-carboxylic acid, 6-hydroxy-, 1,1-dimethylethyl ester, (1R,2S,4S,6R)-; Bicyclic Proline Derivative; exo-Bicyclic Prolinol tert-Butyl Ester
EINECS	Contact for details

Quality Control

Our Exo-6-Hydroxy-2-Aza-Bicyclo[2.2.1]Heptane-2-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.