Description

4'-Bromobiphenyl-4-Yl Trifluoromethanesulfonate is a high-purity, specialized organic intermediate featuring a reactive triflate leaving group. This compound is critical for advanced organic synthesis, particularly in cross-coupling reactions like Suzuki and Stille couplings, enabling the efficient construction of complex biaryl and conjugated systems. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially those containing complex biphenyl scaffolds.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific halogenated biaryl structures.
• Material Science Precursor: Serves as a monomer or precursor in the development of organic electronic materials, such as OLEDs, semiconductors, and liquid crystals.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed Suzuki, Stille, and Negishi couplings to form new carbon-carbon bonds with high efficiency and selectivity.
• Ligand and Catalyst Development: Employed in the synthesis of novel phosphine or N-heterocyclic carbene (NHC) ligands for asymmetric catalysis.
• Chemical Research (R&D): A versatile reagent in academic and industrial research laboratories for exploring new synthetic methodologies and constructing molecular libraries.

Basic Information

Product Name	4'-Bromobiphenyl-4-Yl Trifluoromethanesulfonate
CAS No.	198624-12-3
Molecular Formula	C13H8BrF3O3S
Molecular Weight	381.16 g/mol
Synonyms	4'-Bromo-4-biphenylyl trifluoromethanesulfonate; 4-Bromobiphenyl-4-yl Triflate; (4'-Bromobiphenyl-4-yl) Trifluoromethanesulfonate; 4'-Bromo[1,1'-biphenyl]-4-yl Trifluoromethanesulfonate; 4-Bromo-4'-triflyloxybiphenyl; 4'-Bromobiphenyl-4-ol Triflate; p-Bromobiphenyl-4-yl Triflate; Trifluoromethanesulfonic Acid 4'-Bromobiphenyl-4-yl Ester
EINECS	Contact for details

Quality Control

Our 4'-Bromobiphenyl-4-Yl Trifluoromethanesulfonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided to guarantee reproducible performance in sensitive synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.