Description

Carbamic Acid, [(1R)-1-(Cyanomethyl)Propyl]-, 1,1-Dimethylethyl Ester (9Ci) is a chiral, protected amino acid derivative of significant interest in advanced organic synthesis. This compound, with CAS number 198493-28-6, serves as a crucial high-purity building block for the construction of complex molecules, particularly in pharmaceutical research and development. It is primarily sought after by medicinal chemists and process development scientists working on active pharmaceutical ingredients (APIs), peptide mimetics, and other fine chemicals where stereochemical control is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel drug candidates, especially those targeting neurological and metabolic disorders.
• Peptidomimetics Research: Used to introduce non-natural amino acid residues into peptide backbones to enhance stability, bioavailability, and biological activity.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric reactions to create enantiomerically pure compounds.
• Protecting Group Strategy: The tert-butyloxycarbonyl (Boc) protecting group allows for selective deprotection in complex synthetic sequences.
• Agrochemical Development: Potential use as an intermediate in the synthesis of chiral, biologically active compounds for crop protection.
• Academic & Contract Research: Serves as a valuable reagent in university laboratories and CROs (Contract Research Organizations) for methodological development and discovery chemistry.

Basic Information

Item	Details
Product Name	Carbamic Acid, [(1R)-1-(Cyanomethyl)Propyl]-, 1,1-Dimethylethyl Ester (9Ci)
CAS No.	198493-28-6
Molecular Formula	C10H18N2O2
Molecular Weight	198.26 g/mol
Synonyms	(R)-2-((tert-Butoxycarbonyl)amino)pentanenitrile; (R)-2-((Boc)amino)pentanenitrile; (R)-Boc-Amino-pentanenitrile; (1R)-1-(Cyanomethyl)propylcarbamic acid tert-butyl ester; tert-Butyl N-[(1R)-1-(cyanomethyl)propyl]carbamate; Boc-D-Homoleucine-nitrile; (R)-2-Amino-pentanenitrile, N-Boc-; Boc-(R)-2-amino-pentanenitrile
EINECS	Contact for details

Quality Control

Our Carbamic Acid, [(1R)-1-(Cyanomethyl)Propyl]-, 1,1-Dimethylethyl Ester (9Ci) is produced under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. We provide comprehensive Certificates of Analysis (COA) for each lot, detailing key parameters such as assay, enantiomeric excess (e.e.), and impurity profiles. Our quality commitment aligns with the standards required for GMP starting materials and REACH compliance for global supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.