Description

Peginterferon Alfa-2A is a covalent conjugate of recombinant interferon alfa-2a with a single branched bis-monomethoxy polyethylene glycol (PEG) chain, designed to enhance its pharmacokinetic profile. This modification significantly extends its half-life in the bloodstream, allowing for less frequent dosing while maintaining therapeutic efficacy. It is a critical active pharmaceutical ingredient (API) primarily required by pharmaceutical manufacturers and advanced research institutions developing treatments for chronic viral infections and certain cancers.

Application

• Pharmaceutical API: Primary use as the active ingredient in injectable formulations for the treatment of chronic hepatitis B and C.
• Oncology Therapeutics: Investigated and utilized in combination therapies for certain hematologic malignancies, such as hairy cell leukemia.
• Virology Research: Serves as a key reagent in preclinical and clinical research studying antiviral mechanisms and immune modulation.
• Biosimilar Development: Used as a reference standard or target molecule in the development and analytical testing of biosimilar products.
• Drug Delivery Studies: A model compound in research focused on the impact of PEGylation on protein stability, solubility, and biodistribution.

Basic Information

Product Name	Peginterferon Alfa-2A
CAS No.	198153-51-4
Molecular Formula	C860H1353N229O255S9 (approximate, varies with PEGylation)
Molecular Weight	~60,000 Da (approximate, PEG-conjugated)
Synonyms	Peginterferon alfa-2a; PEG-IFN alfa-2a; Pegylated Interferon Alfa-2A; Interferon alfa-2a PEG conjugate; Pegasys (Brand Name); PEG-Intron (related variant); Polyethylene glycol-modified interferon alfa-2a; Recombinant pegylated interferon α-2a; Monomethoxy polyethylene glycol-interferon alfa-2a conjugate
EINECS	Contact for details

Quality Control

Our Peginterferon Alfa-2A is manufactured under strict cGMP guidelines to ensure the highest standards of purity, potency, and consistency. Each batch is subjected to a comprehensive battery of analytical tests, including but not limited to identity confirmation, purity assessment by advanced chromatographic methods, biological activity assays, and stringent impurity profiling. A detailed Certificate of Analysis (COA) documenting compliance with relevant pharmacopeial standards (e.g., USP, EP) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and must be kept under controlled conditions to maintain stability. Do not freeze unless specified. Keep the container in a dry, cool, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear solution
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 95.0% (Peginterferon Alfa-2A)
Protein Content	As per COA
Biological Activity	As per COA
PEG Content	As per COA
Purity (Related Substances)	Total related proteins ≤ 5.0%
Endotoxins (LAL)	< 10 EU/mg
Sterility (Membrane Filtration)	Sterile
pH	6.5 - 7.5 (in solution)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.