Description

8-Azaspiro[4.5]decane-1-one hydrochloride is a high-purity, nitrogen-containing heterocyclic building block supplied as its stable hydrochloride salt. This compound is a critical intermediate in modern pharmaceutical research and development, valued for its rigid spirocyclic scaffold which is instrumental in creating novel molecular architectures. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of active pharmaceutical ingredients (APIs) and other specialty chemicals.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates targeting central nervous system (CNS) disorders, metabolic diseases, and other therapeutic areas.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its three-dimensional, conformationally restricted structure.
• Process Chemistry & Scale-Up: Serves as a starting material or advanced intermediate in the development of robust, scalable synthetic routes for API manufacturing under GMP conditions.
• Agrochemical Synthesis: Employed in the research and development of new pesticides and herbicides, where the spirocyclic motif can contribute to unique biological activity.
• Chemical Biology Probes: Useful for constructing molecular probes to study enzyme function or protein-protein interactions in biological systems.
• Ligand & Catalyst Development: Potential precursor for nitrogen-containing ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	8-Azaspiro[4.5]decane-1-one hydrochloride
CAS No.	198133-69-6
Molecular Formula	C9H16ClNO
Molecular Weight	189.68 g/mol
Synonyms	1-Oxo-8-azaspiro[4.5]decane hydrochloride; 8-Azaspiro[4.5]decan-1-one HCl; 1-Azaspiro[5.5]undecan-2-one hydrochloride (tautomer); 1-Oxo-8-azaspiro[4.5]decane HCl; 8-Azaspiro[4.5]decan-1-one hydrochloride; 8-Aza-spiro[4.5]decan-1-one hydrochloride; Spiro[4.5]decan-8-one, 1-aza-, hydrochloride
EINECS	Contact for details

Quality Control

Our 8-Azaspiro[4.5]decane-1-one hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.