Description

6-(3-Trifluoromethoxyphenyl)-Nicotinic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique trifluoromethoxy-substituted biphenyl structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring high specificity and metabolic stability. It is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of next-generation small molecule drugs and crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Research: Used in the development of novel herbicides and pesticides, where the trifluoromethoxy group can enhance biological activity and environmental persistence.
• Material Science: Serves as a monomer or functional additive in the creation of specialty polymers and liquid crystals with unique optical or electronic properties.
• Chemical Synthesis: Employed in organic synthesis as a versatile building block for introducing the 3-(trifluoromethoxy)phenyl moiety into more complex molecular architectures.
• Biochemical Tool Compound: Utilized in academic and industrial research as a probe or standard for studying enzyme interactions and metabolic pathways.

Basic Information

Product Name	6-(3-Trifluoromethoxyphenyl)-Nicotinic Acid
CAS No.	197847-91-9
Molecular Formula	C13H8F3NO3
Molecular Weight	283.20 g/mol
Synonyms	6-[3-(Trifluoromethoxy)phenyl]pyridine-3-carboxylic acid; 3-Pyridinecarboxylic acid, 6-[3-(trifluoromethoxy)phenyl]-; 6-(3-Trifluoromethoxyphenyl)nicotinic acid; 6-(α,α,α-Trifluoro-m-tolyloxy)nicotinic acid; Nicotinic acid, 6-(3-trifluoromethoxyphenyl)-; 197847-91-9
EINECS	Contact for details

Quality Control

Every batch of 6-(3-Trifluoromethoxyphenyl)-Nicotinic Acid is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for pharmaceutical R&D and scale-up. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.