Description

Glycine, n-[(1,1-Dimethylethoxy)Carbonyl]-, 1-Methylethyl Ester (9Ci) is a protected amino acid derivative, specifically a Boc-protected glycine isopropyl ester, serving as a crucial building block in organic synthesis. This compound matters for its role in facilitating complex peptide coupling reactions while providing orthogonal protection strategies that are essential for modern medicinal chemistry. Pharmaceutical R&D laboratories and fine chemical manufacturers need this high-purity intermediate for the efficient and scalable production of active pharmaceutical ingredients (APIs), peptide therapeutics, and novel chemical entities.

Application

• Peptide Synthesis: A key intermediate for the controlled, sequential assembly of peptides, particularly in solid-phase peptide synthesis (SPPS) methodologies.
• Pharmaceutical Intermediates: Used in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs) requiring glycine incorporation with specific protecting groups.
• Bioconjugation & Linker Chemistry: Serves as a versatile building block for creating peptide-based linkers used in antibody-drug conjugates (ADCs) and other bioconjugation applications.
• Protecting Group Strategy: The tert-butoxycarbonyl (Boc) group provides acid-labile protection for the amine functionality, allowing for selective deprotection in multi-step syntheses.
• Chemical Biology Research: Employed in the development of peptide probes, enzyme substrates, and other tools for studying biological processes.
• Agrochemical Synthesis: Can be utilized as a synthetic precursor for certain amino acid-derived crop protection agents and plant growth regulators.

Basic Information

Product Name	Glycine, n-[(1,1-Dimethylethoxy)Carbonyl]-, 1-Methylethyl Ester (9Ci)
CAS No.	197579-95-6
Molecular Formula	C10H19NO4
Molecular Weight	217.26 g/mol
Synonyms	Boc-Gly-OiPr; N-Boc-glycine isopropyl ester; N-(tert-Butoxycarbonyl)glycine 1-methylethyl ester; 1-Methylethyl N-[(1,1-dimethylethoxy)carbonyl]glycinate; Isopropyl N-Boc-glycinate; Glycine, N-[(1,1-dimethylethoxy)carbonyl]-, isopropyl ester; Boc-Gly-OPri
EINECS	Contact for details

Quality Control

Our production of Boc-Gly-OiPr adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity suitable for sensitive synthetic applications. All materials are characterized by modern analytical techniques including NMR, HPLC, and MS to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment to prevent hydrolysis.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.